Our gut feeling here (on the Flutter team) is that the speed of hot reload probably depends more on the size of the code that was changed than on total app size.
One thing you could do to get a better idea would be to load up the flutter_gallery application, which was installed when you installed Flutter. It is actually a fairly large application (roughly in the same ballpark as the Hamilton app).
Make a change to a smaller piece of code to see if having a larger app (by itself) slows down hot reload. Then make a change to something large — for example, make a change to the Flutter framework itself. That should definitely take longer.
Needless to say, it would be interesting to see the resulting data.